[AME]Plotkin’s Vaccines, 8th edition (Original PDF)

by Walter A. Orenstein MD DSc (HON) (Author), Paul A. Offit MD (Author), Kathryn M. Edwards MD (Author), & 1 more


From the latest vaccination evidence, recommendations, and protocols . . . to new vaccine development and the use of vaccines in reducing disease, Plotkin’s Vaccines, 8th Edition, covers every aspect of vaccination. Now completely revised and updated from cover to cover, this award-winning text continues to provide reliable information from global authorities, offering a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin’s Vaccines is a must-have reference for current, authoritative information in this fast-moving field.
Contains all-new chapters on COVID-19, vaccine hesitancy, and non-specific effects of vaccines, as well as significantly revised content on new vaccine technologies such as mRNA vaccines, emerging vaccines, and technologies to improve immunization. 

Presents exciting new data on evolution of adjuvants across the centuries, dengue vaccines, human papillomavirus vaccines, respiratory syncytial virus vaccines, tuberculosis vaccines, and zoster vaccines. 

Provides up-to-date, authoritative information on vaccine production, available preparations, efficacy and safety, and recommendations for vaccine use, with rationales and data on the impact of vaccination programs on morbidity and mortality. 

Provides complete coverage of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health and regulatory issues. 

Keeps you up to date with information on each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. 

Covers vaccine-preventable diseases, vaccine science, and licensed vaccine products, as well as product technologies and global regulatory and public health issues. 

Analyzes the cost-benefit and cost-effectiveness of different vaccine options. 

Helps you clearly visualize concepts and objective data through an abundance of tables and figures. 

Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. 

Publisher ‏ : ‎ Elsevier; 8th edition (April 18, 2023)
Language ‏ : ‎ English
Hardcover ‏ : ‎ 1808 pages
ISBN-10 ‏ : ‎ 0323790585
ISBN-13 ‏ : ‎ 978-0323790581

《PLOTKIN'S VACCINES（疫苗学）》自1988年第一版问世以来，不断更新，大约每５年推出一个新的版本。３５年过去，今年4月18日推出的是经过７次更新的第８版。

Stanley Plotkin主编的《PLOTKIN'S VACCINES（疫苗学）》是一本关于疫苗学的经典的权威的大型学术专著，是疫苗学领域的重要参考资料之一，是一部理论和应用相结合、以应用为主的指导免疫规划工作的大型专业参考书，在全球的免疫规划领域享有盛誉。

本书包含了广泛而深入的内容，囊括了疫苗学的各个方面，包括基本概念、疫苗的历史、制备、质量控制、安全性评估、疫苗的效力和免疫机制等，反映了该领域的最新进展。内容增加了关于COVID-19（新冠病毒病）、疫苗犹豫（vaccine hesitancy）和疫苗非特异性效应的全新章节，以及关于新疫苗技术（如mRNA疫苗、新兴疫苗和改进的免疫接种技术)的重大修订内容。重点介绍了新开发或有重大改进的登革热疫苗、人乳头瘤病毒疫苗、呼吸道合胞病毒疫苗、结核病疫苗和带状疱疹疫苗。提供有关疫苗生产、可用制剂、有效性和安全性的最新权威信息，以及疫苗使用建议，并提供有关疫苗接种规划对发病率和死亡率影响的理论和数据。

本书主编Stanley Plotkin是一位享有全球盛誉的疫苗学家和医生，被誉为现代疫苗学的奠基人之一。他在疫苗研究和开发领域有着丰富的经验和杰出的贡献。他曾在制定和发展多种重要疫苗（包括风疹、水痘、脊髓灰质炎等）方面发挥了关键作用。他曾是美国宾夕法尼亚大学儿科学名誉教授、Wistar研究所名誉教授、费城儿童医院传染病科前主任、法国巴斯德梅里埃·康诺(现为赛诺菲·巴斯德)前医学和科学主任。

本书由当今国际疫苗学领域的250多位知名专家共同撰写而成。书中以研究证据和免疫规划实践为基础，对疫苗的发展史、研发过程、生产加工、应用情况、疫苗有效性、安全性、伦理等各方面进行了详细、系统的阐述；以各种疫苗为主线，系统论述当前疫苗相关疾病的世界流行状况、临床诊断、病原微生物学研究进展、疫苗的应用等；增加了新问世和正在研发中的疫苗，并详细介绍了新疫苗的研发生产和检定等内容。

在公共卫生和预防医学中，很少有措施可以与疫苗对疾病负担的影响相比。唯一从地球上消灭的人类疾病是天花，使用第一种发现的疫苗消灭了它。实际上，“疫苗”一词源于拉丁语词汇“vacca”，意为牛，因为这些第一批疫苗是基于从奶女工的牛痘病损中接种脓液到其他人的。此外，由于口服和灭活脊髓灰质炎疫苗的使用，我们现在接近消除野生脊髓灰质炎病毒。2型和3型菌株已被认证为已经消灭，只有1型仍然在巴基斯坦和阿富汗两个国家流行。疫苗特别吸引人，因为大多数疫苗可以在一次或几次接种中提供长期预防重大疾病的效果。这与许多其他公共卫生预防措施形成对比，这些措施需要持续的、常常是终身的行为改变或持续药物使用。