Oxford Textbook of Cancer Biology

Abstract

The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside medical scientists. Oxford Textbook of Cancer Biology brings together the developments from different branches of research into one volume. Structured in seven sections, the book starts with a review of the development and biology of multicellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then ... More

Bibliographic Information

• Publisher:

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• Oxford University Press

• Print Publication Date:

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• May 2019

• Print ISBN-13:

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• 9780198779452

• Published online:

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• Apr 2019

• DOI:

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• 10.1093/med/9780198779452.001.0001

• Contents

• toggleFront Matter

• toggleSection I The multicellular organism

• 1 The multicellular organism and cancerFrancesco Pezzella, David J. Kerr, and Mahvash Tavassoli

• 2 DNA repair and genome integrityGiacomo Buscemi

• 3 Evolution and cancerTom Donnem, Kingsley Micklem, and Francesco Pezzella

• toggleSection II The aetiology of cancer

• 4 Genetics and genetic instability in cancerMark A. Glaire and David N. Church

• 5 EpigeneticsEdward Hookway, Nicholas Athanasou, and Udo Oppermann

• 6 Viral carcinogenesis: An overviewDirk P. Dittmer and Blossom Damania

• 7 Chemical carcinogensDavid H. Phillips

• 8 Radiation as a carcinogenYan-Qun Xiang and Chao-Nan Qian

• toggleSection III How the cancer cell works

• 9 Growth factors and associated signalling pathways in tumour progression and in cancer treatmentNadège Gaborit and Yosef Yarden

• 10 Hormones and cancerBalkees Abderrahman and V. Craig Jordan

• 11 Oncogenesis and tumour suppressionMahvash Tavassoli and Francesco Pezzella

• 12 The signalling pathways in cancerJiangting Hu and Francesco Pezzella

• 13 Cell cycle controlSimon Carr and Nicholas La Thangue

• 14 Cancer and cell deathJessica Bullenkamp and Mahvash Tavassoli

• 15 Telomerase and immortalizationLaura Collopy and Kazunori Tomita

• 16 Cancer metabolismAlmut Schulze, Karim Bensaad, and Adrian L. Harris

• 17 Chaperones and protein quality control in the neoplastic processAndrea Rasola

• 18 Oxygen and cancer: The response to hypoxiaAdrian L. Harris and Margaret Ashcroft

• 19 Invasion, metastasis, and tumour dormancyAndrey Ugolkov and Andrew P. Mazar

• 20 Cancer stem cellsConnor Sweeney, Lynn Quek, Betty Gration, and Paresh Vyas

• toggleSection IV Cancer microenvironment

• 21 Cancer-associated stromaWilma Mesker and Rob Tollenaar

• 22 Blood vessels and cancerFrancesco Pezzella and Robert Kerbel

• 23 Cancer immunology Herman Waldmann

• toggleSection V Global vision of cancer

• 24 Molecular profiling in cancer research and personalized medicinePieter-Jan van Dam and Steven Van Laere

• 25 Proteomics and metabolomics applications in cancer biologyPedro Cutillas and Benedikt M. Kessler

• 26 Cancer systems biology: From molecular profiles to pathways, signalling networks, and therapeutic vulnerabilitiesLieven Verbeke and Steven Van Laere

• 27 Cancer biology through immunohistologyKaren Pulford and Kevin Gatter

• toggleSection VI The biology of cancer treatment

• 28 Principles of chemotherapyDavid J. Kerr, Daniel Haller, and Jaap Verweij

• 29 Immunotherapy and tumour resistance to immune-mediated control and eliminationGwennaëlle C. Monnot and Pedro Romero

• 30 Biological effect of radiotherapy on cancer cellsAnna Dubrovska, Mechthild Krause, and Michael Baumann

• toggleSection VII Conclusions

• 31 Benign tumours: The forgotten neoplasmsFrancesco Pezzella, Adrian L. Harris, and Mahvash Tavassoli

• 32 Conclusions: Cancer biology, a moveable feastDavid J. Kerr, Francesco Pezzella, and Mahvash Tavassoli

• toggleEnd Matter