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This program provides an overview of the structure and functions of the kidneys and details about the major structural compartments of the kidney, including the renal vasculature, glomeruli, tubules, and interstitium. These compartments are discussed at the ultrastructural and molecular levels. Additional discussion includes the functions of these compartments and how they link to structure. Further, integrated functions of the kidneys that lead to the maintenance of body homeostasis are covered.Course Objective(s)Upon completion of the program, the participant will be able to:1) explain the complex course that results in normal nephron and kidney development or congenital abnormalities of the kidneys and urinary tract2) outline the components of the nephron and how they work in concert to form urine3) discuss the varied roles of the kidney in homeostasis and how alterations can result in a range of disorders related to volume, electrolytes, or proteinuria4) identify new research questions to build on current understanding of kidney physiologyContent :On Demand PresentationsOverview of Kidney DevelopmentNorman D. Rosenblum, MDTubule HomeostasisLloyd G. Cantley, MD, FASNCongenital Anomalies of the Kidney and Urinary Tract (CAKUT)Indra R. Gupta, MDGlomerular Structure and FunctionDavid J. Salant, MBChB, MDAbnormalities of Glomerular StructureAstrid Weins, MD, PhD, FASNRenal Vasculature and HemodynamicsHeather A. Drummond, PhDControl of Volume and OsmolalityJoseph G. Verbalis, MDEndocrine Functions of the KidneysMitchell H. Rosner, MD, FASNMechanisms of Hypertension and the KidneysJordana B. Cohen, MD, MS, FASNThe Renal InterstitiumDennis G. Moledina, MD, PhD, FASNDefining Tubular SegmentsMark A. Knepper, MD, PhDProximal TubuleMelanie P. Hoenig, MDThick Ascending Limb of the Loop of HenleJeff M. Sands, MD, FASNDistal Convoluted TubuleEwout J. Hoorn, MD, PhDCollecting DuctNuria M. Pastor-Soler, MD, PhD, FASNLivestreamPresentationsWelcome and Introduction - Co-Chairs01:30 PM EDT - 01:35 PM EDTEmerging Technologies for Studying the Glomerular Filtration Barrier01:35 PM EDT - 02:00 PM EDTSargis Sedrakyan, PhDUrinary Single-Cell Profiling02:00 PM EDT - 02:25 PM EDTKatalin Susztak, MD, PhDExtracellular Vesicles02:25 PM EDT - 02:50 PM EDTUta Erdbruegger, MDPanel Discussion and Q&A02:50 PM EDT - 03:00 PM EDT
