Mitochondria and Anaerobic Energy Metabolism in Eukaryotes Biochemistry and Evolution

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Mitochondria and Anaerobic Energy Metabolism in Eukaryotes Biochemistry and Evolution

William F. MartinAloysius G. M. Tielens and Marek Mentel

Mitochondria and Anaerobic Energy Metabolism in Eukaryotes

Biochemistry and Evolution

    De Gruyter 2021

    DOI: https://doi.org/10.1515/9783110612417



    Mitochondria and Anaerobic Energy Metabolism in Eukaryotes Biochemistry and Evolution.jpg

    DETAILS
    • Language: English

    • Publisher: De Gruyter

    • Copyright year: 2021

    • Audience: researchers, specialists and graduate students in biology, biochemistry and molecular biology

    • Pages:

      • Front matter: 17

      • Main content: 252

    • Illustrations:

      • Coloured Illustrations: 34

    • Keywords: MetabolismEukaryotesMitochondriaEvolution

    ABOUT THIS BOOK


    Mitochondria are sometimes called the powerhouses of eukaryotic cells, because mitochondria are the site of ATP synthesis in the cell. ATP is the universal energy currency, it provides the power that runs all other life processes. Humans need oxygen to survive because of ATP synthesis in mitochondria. The sugars from our diet are converted to carbon dioxide in mitochondria in a process that requires oxygen. Just like a fire needs oxygen to burn, our mitochondria need oxygen to make ATP. From textbooks and popular literature one can easily get the impression that all mitochondria require oxygen. But that is not the case. There are many groups of organismsm known that make ATP in mitochondria without the help of oxygen. They have preserved biochemical relicts from the early evolution of eukaryotic cells, which took place during times in Earth history when there was hardly any oxygen avaiable, certainly not enough to breathe. How the anaerobic forms of mitochondria work, in which organisms they occur, and how the eukaryotic anaerobes that possess them fit into the larger picture of rising atmospheric oxygen during Earth history are the topic of this book.



    • comprehensive overview about the anaerobic forms of mitochondria

    • embedding in the evolutionary context


    AUTHOR INFORMATION

    William F. Martin, Düsseldorf, Aloysius G. M. Tielens, Rotterdam, Marek Mentel, Bratislava

    Frontmatter
     Free access PDF 
    I
    Preface
     Free access PDF 
    VII
    Contents
     Free access PDF 
    IX
    List of figures
     Free access PDF 
    XIII
    List of abbreviations
     Free access PDF 
    XV
    PART I: BASICS
    Introduction
     
    3
    1 Anaerobes and eukaryote origin
     
    7
    2 Eukaryotes in low oxygen environments

    13
    3 A modern context of atmospheric evolution

    18
    4 Energy metabolism and redox balance
     
    23
    5 Fermentation, glycolysis, and compartmentation
     
    26
    6 Respiration is not always aerobic
     
    36
    7 Using oxygen can be optional
     
    42
    8 The hypoxia-inducible factor (HIF)
     
    48
    9 O2 dependent fermentations in trypanosomes
     
    52
    10 Anaerobic mitochondria
     
    58
    11 Mitochondria with and without oxygen

    61
    12 Hydrogenosomes and H2-producing mitochondria
     
    64
    13 Mitosomes and microaerophilia

    68
    14 Other organelles of mitochondrial origin
     
    73
    15 Genomes are not alive

    78
    PART II: WELL-STUDIED EXAMPLES
    Introduction

    83
    16 Anaerobic use of the mitochondrial electron-transport chain
     
    85
    17 Naegleria gruberi, a strict aerobe with an “anaerobic genome”
     Access restricted
    89
    18 Malate dismutation in the liver fluke Fasciola hepatica
     Access restricted
    92
    19 The roundworms Ascaris suum and Ascaris lumbricoides
     Access restricted
    97
    20 Animals in tidal zones, anaerobic sediments and sulfide
     Access restricted
    101
    21 Anaerobic respiration in eukaryotes, rare but there
     Access restricted
    115
    22 Enzymes of anaerobic energy metabolism in algae
     Access restricted
    124
    23 Wax ester fermentation in Euglena gracilis
     Access restricted
    127
    24 Chlamydomonas reinhardtii, a jack of all trades
     Access restricted
    131
    25 Organisms with hydrogenosomes
     Access restricted
    136
    26 Nyctotherus ovalis and H2-producing mitochondria
     Access restricted
    151
    27 Energy metabolism in organisms with mitosomes
     Access restricted
    160
    28 Energy parasites
     Access restricted
    168
    PART III: EVOLUTION
    Introduction
     Free access PDF 
    175
    29 Why did mitochondria become synonymous with O2?
     Free access PDF 
    176
    30 Ubiquitous mitochondria among anaerobes
     Free access PDF 
    180
    31 Differential loss from a facultative anaerobic ancestral state
     Access restricted
    186
    32 Oxygen availability in early eukaryote evolution: the Pasteurian
     Access restricted
    190
    33 Evolution with mitochondrial energy metabolism
     Access restricted
    201
    34 Envoi
     Access restricted
    208
    Bibliography
     Access restricted
    211
    Index
     Access restricted
    249





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