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In Molecular Diagnostics: Cancer Diagnosis and Patient Management, experts in the field review current concepts and up-to-date techniques, delving into the appropriate use of molecular assays for different tumor types to inform diagnosis, prognosis, or treatment using evidence-based guidelines.Lectures in this online CME course illustrate common diagnostic pitfalls, with additional focus on variant interpretation and the complexity of billing for molecular tests. It’s continuing medical education that will help you to:Develop appropriate tissue-handling protocolsEvaluate cytogenetic and molecular techniques, including next generation sequencing assaysRecognize cost-effective, time-sensitive approaches to molecular studies, including cell free DNA testingDetermine the process of clinical interpretation of genetic variationAnalyze costs and potential sources of revenue for molecular diagnostics programsConsider essential and emerging biomarkers in common adult and pediatric solid and liquid tumorsLearning ObjectivesUpon completion of this activity, participants will be better able to:Develop appropriate tissue-handling protocols to facilitate molecular testingEvaluate cytogenetic and molecular techniques including different types of next generation sequencing assaysRecognize cost-effective and time-sensitive approaches to molecular studies in cancer diagnostics, including implementation of cell free DNA testingDetermine the process of the clinical interpretation of genetic variationAnalyze the costs and potential sources of revenue for molecular diagnostics programsConsider essential and emerging molecular biomarkers in a range of common adult and pediatric solid and liquid tumorsTarget AudienceThis course will help pathologists, oncologists, and PhD-trained staff working in molecular diagnostic laboratories or in the pharmaceutical industry, as well as trainees in Oncology and Pathology.TOPICS / SPEAKERSAn Introduction to Molecular Diagnostics - Fei Dong, MDSpecimen Handling for Molecular Success - Lynette M. Sholl, MDAn Introduction to Cytogenetic Techniques - Azra Ligon, PhDQuestion and Answer Session - Moderator - Valentina Nardi, MD; Drs. Dong, Sholl, and LigonAn Introduction to Next Generation Sequencing - Laura MacConaill, PhDAn Introduction to Bioinformatic Pipelines for NGS - Ryan J. Schmidt, MD, PhDQuestion and Answer Session - Moderator - Valentina Nardi, MD; Drs. MacConaill and SchmidtAn Introduction to Liquid Biopsy (Cell Free DNA Sequencing) - Technical Topics - Long Phi Le, MD, PhDAn Introduction to Liquid Biopsy (Cell Free DNA Sequencing) - Clinical Applications - Giulia Siravegna, PhDTumor Mutation Burden and Microsatellite Instability Testing - Jonathan Nowak, MD, PhDQuestion and Answer Session - Moderator - Valentina Nardi, MD; Drs. Le, and NowakLive Advanced Workshop: Informatics - Long Phi Le, MD, PhDMolecular Diagnostics for Breast Cancer - Deborah Dillon, MDMolecular Diagnostics of Gynecologic Tumors - Lauren Ritterhouse, MD, PhDQuestion and Answer Session - Moderator - Lynette M. Sholl, MD; Drs. Dillon and RitterhouseMolecular Diagnostics of Melanoma - Ryan J. Sullivan, MDMolecular Diagnostics of Pediatric and Rare Tumors - Valentina Nardi, MDMetastatic Inflammatory Myofibroblastic Tumor - Alanna Church, MD and Katherine Janeway, MD, MMScQuestion and Answer Session - Moderator - Lynette M. Sholl, MD; Drs. Church, Janeway and SullivanClinical Interpretation of Sequence and Copy Number Variants (Cancer NGS) - Fei Dong, MDClinical Interpretation for Gene Fusions - Valentina Nardi, MDClinical Interpretation of Germline Cancer Predisposition - Diana Mandelker, MD, PhDQuestion and Answer Session - Moderator - Lynette M. Sholl, MD; Drs. Dong, Mandelker, and NardiLive Advanced Workshop: Fusion Interpretation - Adam Fisch, MD, PhDHot Topics in Myeloid Neoplasms - Valentina Nardi, MDHot Topics in Measurable (Minimal) Residual Disease Testing - Annette S. Kim, MD, PhDTargetable Fusions in Acute Lymphoblastic Leukemia - Marian H. Harris, MD, PhDQuestion and Answer Session - Moderator - Lynette M. Sholl, MD; Drs. Harris, Nardi and KimMolecular Diagnostics for B-cell Lymphomas - Scott B. Lovitch, MD, PhDMolecular Diagnostics for T-cell Lymphomas - David Weinstock, MDHematological Malignancy Case Presentation - Hanno Hock, MD, PhD and Valentina Nardi, MDQuestion and Answer Session - Moderator - Lynette M. Sholl, MD; Drs. Lovitch, Nardi, Weinstock, and HockMolecular Diagnostics for Sarcomas - Adrian Marino-Enriquez, MD, PhDMolecular Diagnostics for Gliomas - David Meredith, MD, PhDClinical Applications of Whole Genome DNA Methylation Profiling - Matija Snuderl, MDQuestion and Answer Session - Moderator - Valentina Nardi, MD; Drs. Marino-Enriquez, Meredith, and SnuderlAdvanced Workshop: Copy Number by Microarray & NGS - Adrian Dubuc, PhDMolecular Diagnostics for Lung Cancer - Lynette M. Sholl, MDMolecular Diagnostics for Thyroid Cancer - Dora Dias-Santagata, PhD, FACMGQuestion and Answer Session - Moderator - Valentina Nardi, MD; Drs. Dias-Santagata and ShollMolecular Biomarkers for GU Cancers - Atish Choudhury, MD, PhDMolecular Diagnostics for GI Cancers - Jonathan Nowak, MD, PhDClinical Case Presentation and Discussion (Lung Tumor) - Mark M. Awad, MD, PhD and Lynette M. Sholl, MDQuestion and Answer Session - Moderator - Valentina Nardi, MD; Drs. Awad, Sholl, Choudhury, and NowakBilling and Regulatory Issues - Jochen K. Lennerz, MD, PhDOpportunities in Molecular Lab Management - Neal Lindeman, MDClinical Trials and Regulatory Affairs - Hetal Marble, PhDQuestion and Answer Session - Moderator - Valentina Nardi, MD; Drs. Iafrate, Lennerz, Lindeman, and MarbleDate of Original Release: October 30, 2021Termination Date: January 31, 2024
