Biological Small Angle Scattering: Theory and Practice

Eaton E. Lattman, Thomas D. Grant, and Edward H. Snell

ABSTRACT

The technique of small angle solution scattering has been revolutionized in the last two decades. Exponential increases in computing power, parallel algorithm development, and the development of synchrotron, free-electron X-ray sources, and neutron sources, have combined to allow new classes of studies for biological specimens. These include time-resolved experiments in which functional motions of proteins are monitored on a picosecond timescale, and the first steps towards determining actual electron density fluctuations within particles. In addition, more traditional experiments involving th ... More

Keywords: Small angle solution scattering, Small angle X-ray scattering, Small angle neutron scattering, Biological solutions, Practical guidance, Application examples

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